CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure
نویسندگان
چکیده
منابع مشابه
Spinal Cord Injury and CNS Regeneration
Neurological rehabilitation is expanding its scope to include restoration of function through regeneration. However, this complex task will require multi-stage interventions, some easier to achieve than others. Of repair strategies on the horizon, harnessing the potential of neural stem cells already present in the CNS and placed there by transplantation appears promising. In fact, using stem c...
متن کاملDistinctive response of CNS glial cells in oro-facial pain associated with injury, infection and inflammation
Oro-facial pain following injury and infection is frequently observed in dental clinics. While neuropathic pain evoked by injury associated with nerve lesion has an involvement of glia/immune cells, inflammatory hyperalgesia has an exaggerated sensitization mediated by local and circulating immune mediators. To better understand the contribution of central nervous system (CNS) glial cells in th...
متن کاملStrategies for nerve regeneration after CNS injury
It was traditionally thought that the central nerve system (CNS) defects the regenerated ability, following the injury. However, the peripheral nerve system (PNS) possesses an ability of regeneration after injury. Also it was found that the axon in CNS might extend into the graft, as soon as the peripheral nerve tissue was transplanted into the injured part of CNS. Therefore, it implied that th...
متن کاملSynthetic extracellular matrices for tissue engineering and regeneration.
The need for replacement tissues or organs requires a tissue supply that cannot be satisfied by the donor supply. The tissue engineering and regeneration field is focused on the development of biological tissue and organ substitutes and may provide functional tissues to restore, maintain, or improve tissue formation. This field is already providing new therapeutic options to bypass the limitati...
متن کاملAbrogation of β-catenin signaling in oligodendrocyte precursor cells reduces glial scarring and promotes axon regeneration after CNS injury.
When the brain or spinal cord is injured, glial cells in the damaged area undergo complex morphological and physiological changes resulting in the formation of the glial scar. This scar contains reactive astrocytes, activated microglia, macrophages and other myeloid cells, meningeal cells, proliferating oligodendrocyte precursor cells (OPCs), and a dense extracellular matrix. Whether the scar i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2008
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2007.05.014